Analysis Tools
mortality/aging
|
• pups die shortly after birth
|
vision/eye
|
• a range of eye phenotypes from mild bilateral microphthalmia to severe anophthalmia
|
|
• disrupted cell layering consisting of rosette structures
|
|
• 30%-40% thinner than wild-type retinas
• reduction in cell number
|
anophthalmia
(
J:108452
)
digestive/alimentary system
| N |
• no defects in sensory innervation of the tongue are apparent
|
|
• taste buds are absent in the mutant palate at P0
|
|
• no defects in the initial number, morphology or distribution of fungiform papillae
• by E16.5-18.5, fewer fungiform papillae are present compared to controls
• from E14.5-E18, a gradual reduction in the size and morphology of the fungiform papillae is seen
• fungiform taste buds, detected by keratin 8 immunostaining, are absent in P0 mutant tongues
• no abnormalities are seen in the filiform papillae at any stage
|
craniofacial
|
• taste buds are absent in the mutant palate at P0
|
|
• no defects in the initial number, morphology or distribution of fungiform papillae
• by E16.5-18.5, fewer fungiform papillae are present compared to controls
• from E14.5-E18, a gradual reduction in the size and morphology of the fungiform papillae is seen
• fungiform taste buds, detected by keratin 8 immunostaining, are absent in P0 mutant tongues
• no abnormalities are seen in the filiform papillae at any stage
|
growth/size/body
|
• taste buds are absent in the mutant palate at P0
|
|
• no defects in the initial number, morphology or distribution of fungiform papillae
• by E16.5-18.5, fewer fungiform papillae are present compared to controls
• from E14.5-E18, a gradual reduction in the size and morphology of the fungiform papillae is seen
• fungiform taste buds, detected by keratin 8 immunostaining, are absent in P0 mutant tongues
• no abnormalities are seen in the filiform papillae at any stage
|
taste/olfaction
|
• taste buds are absent in the mutant palate at P0
|
