Phenotypes Associated with This Genotype

Genotype
MGI:3625463

• Allelic Composition: Adora2a^tm1Dyj/Adora2a^tm1.1Dyj; Tg(Camk2a-cre)1Szi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:104338 )

• daily treatment with amphetamine enhances locomotor responses in male control mice but does not affect male mutants; 1 week after cessation of treatment robust locomotor sensitization persists in controls

abnormal locomotor activation ( J:102700 , J:104338 )

• control mice exhibit greater locomotor response when treated with a Grm5 antagonist, MPEP, than forebrain-specific knockout mice (J:102700)

• in response to the adenosine (A2a) agonist KW-6002, locomotion is induced in male control animals but not in conditional knockout mice (J:104338)

• enhancement of fine movement behavior in male controls is observed in response to amphetamine treatment but not in knockouts (J:104338)