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Phenotypes Associated with This Genotype
Genotype
MGI:3625315
Allelic
Composition		 Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcls1tm2Wtn mutation (0 available); any Hcls1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
decreased B cell number ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
abnormal B cell physiology ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown

immune system
decreased T cell proliferation ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
decreased B cell number ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
abnormal B cell physiology ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
abnormal humoral immune response ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown

cellular
decreased T cell proliferation ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory