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Phenotypes Associated with This Genotype
Genotype
MGI:3625288
Allelic
Composition
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• unlike macrophages from wild-type mice, macrophages from Cias1-deficient mice do not release significant amounts of Il-1beta or Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+
• null mice secrete much lower serum levels of Il-1beta and Il-18 after receiving a lethal LPS dose
• in response to a lethal dose of LPS, all injected wild-type mice die within 48 hours of caspase-1-dependent endotoxic shock, but only 30% of Cias-null mice die after 72 hours
• macrophages from null mice show reduced Il-1beta and Il-18 release and no caspase-1 activation when infected with S. aureus or Listeria compared to wild-type macrophages in culture
• S. aureus infection induces more macrophage death in cells from null animals compared to wild-type macrophages in culture


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory