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Phenotypes Associated with This Genotype
Genotype
MGI:3625286
Allelic
Composition
Nlrc4tm1Vmd/Nlrc4tm1Vmd
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation (1 available); any Nlrc4 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory