Phenotypes Associated with This Genotype

Genotype
MGI:3624986

• Allelic Composition: Tg(Ckm-LPL)LRze/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:101818 )

• between 12 and 18 months of age, lose weight and die prematurely

growth/size/body

decreased body weight ( J:101818 )

• do not exhibit slow weight gain during the initial 12 weeks after birth

weight loss ( J:101818 )

• between 12 and 18 months of age, lose weight and die prematurely

muscle

abnormal skeletal muscle morphology ( J:101818 )

• moderate increase in the number of peroxisomes in skeletal muscle

homeostasis/metabolism

decreased circulating triglyceride level ( J:101818 )

• 44.2% decrease in plasma triglyceride levels at 2-3 months of age, with lower levels seen over the lifespan of mutants

decreased circulating VLDL triglyceride level ( J:101818 )

increased catalase activity ( J:101818 )

• 4-fold increase in catalase activity in skeletal muscle

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myopathy		DOID:423		J:101818