Analysis Tools
mortality/aging
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• mean longevity for males is 155 +/- 13 days compared to 442 +/- 29 days for littermate females
(J:6235)
• castration does not significantly alter longevity
(J:6235)
• median survival is 8 months
(J:7308)
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immune system
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• 4-fold increase in spleen weight
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• frequency of C3d receptor bearing cells is increased in young mice but declines with age
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• increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females
• frequency of Ig-bearing cells is increased in the thymus
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• at 14 weeks of age, more than normal splenic CD4+ Foxp3+ CD25+ T cells and very few splenic CD8+ Foxp3+ CD25+ T cells and higher than normal expression of CD122 on CD8+ splenic T cells
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• increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age
• at 8 months of age a 16-fold increase in monocytes is seen in males compared to females
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• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
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• relative to BXSB.B6-Yaa+ at 14 weeks of age but not at 6 weeks of age
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(J:93740)
(J:179430)
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• relative to BXSB.B6-Yaa+ controls
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• relative to BXSB.B6-Yaa+ controls
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• infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node
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• moderately enlarged
• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
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• accelerated autoimmune syndrome relative to females of the same strain
(J:6235)
(J:108760)
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• erythrocyte autoantibodies were found in 7 of 13 males between 16 and 25 weeks of age
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• serum anti-nuclear antibodies are found at 6 weeks of age and increased levels at 14 weeks of age
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• acute to subacute exudative and proliferative glomerulonephritis
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hematopoietic system
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• 4-fold increase in spleen weight
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• frequency of C3d receptor bearing cells is increased in young mice but declines with age
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• decreased at 16 weeks of age compared to C57BL/6J males
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• increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females
• frequency of Ig-bearing cells is increased in the thymus
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• at 14 weeks of age, more than normal splenic CD4+ Foxp3+ CD25+ T cells and very few splenic CD8+ Foxp3+ CD25+ T cells and higher than normal expression of CD122 on CD8+ splenic T cells
|
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• increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age
• at 8 months of age a 16-fold increase in monocytes is seen in males compared to females
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• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
|
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• relative to BXSB.B6-Yaa+ at 14 weeks of age but not at 6 weeks of age
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(J:93740)
(J:179430)
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• relative to BXSB.B6-Yaa+ controls
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• relative to BXSB.B6-Yaa+ controls
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renal/urinary system
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• seen at 4 months of age
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• acute to subacute exudative and proliferative glomerulonephritis
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• glomerular depositions of IgG are found at 14 weeks of age
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homeostasis/metabolism
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• seen at 4 months of age
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growth/size/body
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• 4-fold increase in spleen weight
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:6235 , J:7308 , J:108760 | |
