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Phenotypes Associated with This Genotype
Genotype
MGI:3624726
Allelic
Composition
Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die sometime around E9.5 (J:82084)
• die sometime around E9.5 (J:82084)

nervous system
• a sharp boundary between the neural plate and the rest of the ectoderm is absent (J:82084)
• a sharp boundary between the neural plate and the rest of the ectoderm is absent (J:82084)
• lack postotic vagal level neural crest cells (J:82084)
• lack postotic vagal level neural crest cells (J:82084)
• neural tube fails to close (J:82084)
• neural tube fails to close (J:82084)

embryogenesis
• cranial neural crest cells do not delaminate nor do they initiate migration (J:82084)
• cranial neural crest cells do not delaminate nor do they initiate migration (J:82084)
• the first branchial arch is missing (J:82084)
• the first branchial arch is missing (J:82084)
• do not undergo embryonic turning (J:82084)
• do not undergo embryonic turning (J:82084)
• a sharp boundary between the neural plate and the rest of the ectoderm is absent (J:82084)
• a sharp boundary between the neural plate and the rest of the ectoderm is absent (J:82084)
• lack postotic vagal level neural crest cells (J:82084)
• lack postotic vagal level neural crest cells (J:82084)
• neural tube fails to close (J:82084)
• neural tube fails to close (J:82084)
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm (J:82084)
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm (J:82084)
• embryos are severely retarded in growth by E9.5 (J:82084)
• embryos are severely retarded in growth by E9.5 (J:82084)

craniofacial
• the first branchial arch is missing (J:82084)
• the first branchial arch is missing (J:82084)

cellular
• cranial neural crest cells do not delaminate nor do they initiate migration (J:82084)
• cranial neural crest cells do not delaminate nor do they initiate migration (J:82084)

Mouse Models of Human Disease
OMIM ID Ref(s)
Mowat-Wilson Syndrome; MOWS 235730 J:82084


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory