Mouse Genome Informatics
hm
    Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

nervous system
• a sharp boundary between the neural plate and the rest of the ectoderm is absent
• lack postotic vagal level neural crest cells
• neural tube fails to close

embryogenesis
• cranial neural crest cells do not delaminate nor do they initiate migration
• the first branchial arch is missing
• do not undergo embryonic turning
• a sharp boundary between the neural plate and the rest of the ectoderm is absent
• lack postotic vagal level neural crest cells
• neural tube fails to close
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm
• embryos are severely retarded in growth by E9.5

craniofacial
• the first branchial arch is missing

cellular
• cranial neural crest cells do not delaminate nor do they initiate migration

Mouse Models of Human Disease
OMIM IDRef(s)
Mowat-Wilson Syndrome; MOWS 235730 J:82084