Phenotypes Associated with This Genotype

Genotype
MGI:3624553

• Allelic Composition: Mecp2^tm1Hzo/Y
• Genetic Background: 129S7/SvEvBrd-Mecp2^tm1Hzo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:78009 )

♂ • 100% of males display tremors

impaired coordination ( J:78009 )

♂ • performance on a thin horizontal wooden dowel is impaired in older (35-36 weeks of age) but not younger (8-9 weeks of age) males

♂ • in the wire suspension test, young males (8-9 weeks of age drop earlier than wild-type

increased stereotypic behavior ( J:78009 )

♂ • 100% of males display stereotypic forepaw movements (rapid and repetitive movement of the forelimbs, often bring them together)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:78009