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Phenotypes Associated with This Genotype
Genotype
MGI:3624520
Allelic
Composition
Dnah5Tg1Htz/Dnah5Tg1Htz
Genetic
Background
involves: C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnah5Tg1Htz mutation (0 available); any Dnah5 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die during the first 2-3 weeks of life

respiratory system
• nasal epithelium cilia are immotile and lack dynein outer arms
• paranasal sinuses show excess mucus containing numerous white blood cells

nervous system
• seen as early as 3-5 days after birth and develops to severe enlargement of the lateral ventricles leading to thinning of the cerebral cortex, multiple hemorrhages, and compression of the cerebellum
• severe enlargement of the lateral ventricles
• hydroencephalus leads to thinning of the cerebral cortex
• compression and atrophy of the cerebellum

growth/size/body
• mutants exhibit either complete (both dextrocardia and reversal of the abdominal organs), partial, or no situs inversus

craniofacial
• skull is expanded

hearing/vestibular/ear
• fail to respond to noise
• examination of the middle ear shows severe infection in the timpanic cavity

immune system
• examination of the middle ear shows severe infection in the timpanic cavity
• paranasal sinuses show excess mucus containing numerous white blood cells

behavior/neurological

skeleton
• skull is expanded

cellular
• nasal epithelium cilia are immotile and lack dynein outer arms


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory