Mouse Genome Informatics
hm
    Dnah5Tg1Htz/Dnah5Tg1Htz
involves: C57BL/6 * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die during the first 2-3 weeks of life

respiratory system
• nasal epithelium cilia are immotile and lack dynein outer arms
• paranasal sinuses show excess mucus containing numerous white blood cells

nervous system
• seen as early as 3-5 days after birth and develops to severe enlargement of the lateral ventricles leading to thinning of the cerebral cortex, multiple hemorrhages, and compression of the cerebellum
• severe enlargement of the lateral ventricles
• hydroencephalus leads to thinning of the cerebral cortex
• compression and atrophy of the cerebellum

growth/size
• mutants exhibit either complete (both dextrocardia and reversal of the abdominal organs), partial, or no situs inversus

craniofacial
• skull is expanded

hearing/vestibular/ear
• fail to respond to noise
• examination of the middle ear shows severe infection in the timpanic cavity

immune system
• examination of the middle ear shows severe infection in the timpanic cavity
• paranasal sinuses show excess mucus containing numerous white blood cells

behavior/neurological

skeleton
• skull is expanded

cellular
• nasal epithelium cilia are immotile and lack dynein outer arms

Mouse Models of Human Disease
OMIM IDRef(s)
Ciliary Dyskinesia, Primary, 3; CILD3 608644 J:76189
Otitis Media, Susceptibility to 166760 J:76189