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Phenotypes Associated with This Genotype
Genotype
MGI:3624367
Allelic
Composition
Ctnna2tm1Mta/Ctnna2tm1Mta
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna2tm1Mta mutation (0 available); any Ctnna2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die with 24 hours after birth

nervous system
• null mutants show some subtle disorders in laminar formation in the hippocampus
• Purkinje cell migration in the cerebellum is partially blocked in null mice
• dendrites of cultured hippocampal neurons from null mutants differ in their fine morphology compared to wild-type neurons; many dendritic spines are elongated in mutant neurons, with variable length of the dendritic spines

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:83635


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory