Phenotypes Associated with This Genotype

Genotype
MGI:3624271

• Allelic Composition: Dync2h1^lln/Dync2h1^lln
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100466 )

• homozygous mutants die around E12.5

embryo

embryo phenotype ( J:100466 )

N • around E7.5, cilia present on the surface of the node are abnormal; some cilia are short while others are normal in length but have a bulge along their surface

cardiovascular system

abnormal direction of heart looping ( J:100466 )

• mutants exhibit randomization of heart looping polarity

limbs/digits/tail

polydactyly ( J:100466 )

• mutants surviving to E13.5 display polydactyly of the fore- and hind-limbs

nervous system

exencephaly ( J:100466 )

• about 50% of homozygotes are exencephalic and lack the groove at the ventral midline of the brain