Mouse Genome Informatics
involves: 129S4/SvJae
phenotype observed in females
phenotype observed in males
N normal phenotype
• in response to a diabetogenic streptozotocin dose, null mice do not develop hyperglycemia in the first 7 days and show only a transient 1.7-fold blood glucose increase over untreated control levels on day 21, compared to treated controls which have a gradual increase in blood glucose over this period and still exhibit elevated levels on day 60
• streptozotocin treatment causes beta cell death and atrophy in pancreatic islets from treated wild-type mice over 60 days of observation, but islets from null mice show very little damage

Mouse Models of Human Disease
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:53360