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Phenotypes Associated with This Genotype
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parp1tm1Hsmm mutation (8 available); any Parp1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• in response to a diabetogenic streptozotocin dose, null mice do not develop hyperglycemia in the first 7 days and show only a transient 1.7-fold blood glucose increase over untreated control levels on day 21, compared to treated controls which have a gradual increase in blood glucose over this period and still exhibit elevated levels on day 60
• streptozotocin treatment causes beta cell death and atrophy in pancreatic islets from treated wild-type mice over 60 days of observation, but islets from null mice show very little damage

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:53360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory