Phenotypes Associated with This Genotype

Genotype
MGI:3623594

• Allelic Composition: Tg(Igh-6/Igh-V125)2Jwt/0; Tg(Igk-C/Igk-V125)1Jwt/0
• Genetic Background: NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:91865 )

• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system

insulitis ( J:91865 )

• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

abnormal B cell number ( J:91865 )

• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice

increased susceptibility to autoimmune diabetes ( J:91865 )

• transgenic females develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at an accelerated rate; 95% develop diabetes by 40 weeks

hematopoietic system

abnormal B cell number ( J:91865 )

• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice

homeostasis/metabolism

increased circulating glucose level ( J:91865 )

• mice are diabetic if 2 consecutive blood glucose measurements are >200 mg/dl

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:91865