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Phenotypes Associated with This Genotype
Genotype
MGI:3623594
Allelic
Composition
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
Genetic
Background
NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh-6/Igh-V125)2Jwt mutation (1 available)
Tg(Igk-C/Igk-V125)1Jwt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice
• transgenic females develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at an accelerated rate; 95% develop diabetes by 40 weeks

hematopoietic system
• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice

homeostasis/metabolism
• mice are diabetic if 2 consecutive blood glucose measurements are >200 mg/dl

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:91865


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory