Mouse Genome Informatics
cx
    Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0

NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice
• transgenic females develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at an accelerated rate; 95% develop diabetes by 40 weeks

hematopoietic system
• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice

homeostasis/metabolism
• mice are diabetic if 2 consecutive blood glucose measurements are >200 mg/dl

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:91865