Mouse Genome Informatics
hm
    B2mtm1Unc/B2mtm1Unc
NOD.129P2-B2mtm1Unc
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• homozygous-null NOD mice show almost no insulitis and still possess normal beta cells; control NOD mice show insulitis and a high degree of beta cell destruction

immune system
• mice lack CD8+ T cells
• no homozygous mice become diabetic by 4 months of age, while over 70% of control NOD mice become diabetic (blood glucose >16.7 mM; positive urine glucose test) by 4 months of age (J:17000)
• females remain disease-free compared (J:121685)

hematopoietic system
• mice lack CD8+ T cells

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:17000