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Phenotypes Associated with This Genotype
Genotype
MGI:3623523
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Genetic
Background
NOD.129P2-B2mtm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (37 available); any B2m mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• homozygous-null NOD mice show almost no insulitis and still possess normal beta cells; control NOD mice show insulitis and a high degree of beta cell destruction

immune system
• mice lack CD8+ T cells
• no homozygous mice become diabetic by 4 months of age, while over 70% of control NOD mice become diabetic (blood glucose >16.7 mM; positive urine glucose test) by 4 months of age (J:17000)
• females remain disease-free compared (J:121685)

hematopoietic system
• mice lack CD8+ T cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
J:17000


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory