Mouse Genome Informatics
tg
    Tg(Ins1-Cat,Tyr)25Pne/0
involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells
• for the first 3 days after streptozocin injection, transgenic mice have decreased blood glucose levels compared to injected control mice; by day 4 transgenic and control mice are diabetic
• catalase activity in pancreatic islet cells transgenic mice is 50-fold increased over levels in control islet cells
• in response to streptozocin, a beta-cell toxin, transgenic mice display a significantly delayed diabetogenic to a single injection, compared to control mice

endocrine/exocrine glands
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:59725