About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3623483
Allelic
Composition
Tg(Ins1-Cat,Tyr)25Pne/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins1-Cat,Tyr)25Pne mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells (J:59275)
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells (J:59275)
• for the first 3 days after streptozocin injection, transgenic mice have decreased blood glucose levels compared to injected control mice; by day 4 transgenic and control mice are diabetic (J:59275)
• for the first 3 days after streptozocin injection, transgenic mice have decreased blood glucose levels compared to injected control mice; by day 4 transgenic and control mice are diabetic (J:59275)
• catalase activity in pancreatic islet cells transgenic mice is 50-fold increased over levels in control islet cells (J:59275)
• catalase activity in pancreatic islet cells transgenic mice is 50-fold increased over levels in control islet cells (J:59275)
• in response to streptozocin, a beta-cell toxin, transgenic mice display a significantly delayed diabetogenic to a single injection, compared to control mice (J:59275)
• in response to streptozocin, a beta-cell toxin, transgenic mice display a significantly delayed diabetogenic to a single injection, compared to control mice (J:59275)

endocrine/exocrine glands
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells (J:59275)
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells (J:59275)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:59725


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory