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Phenotypes Associated with This Genotype
Genotype
MGI:3623483
Allelic
Composition
Tg(Ins1-Cat,Tyr)25Pne/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins1-Cat,Tyr)25Pne mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells
• for the first 3 days after streptozocin injection, transgenic mice have decreased blood glucose levels compared to injected control mice; by day 4 transgenic and control mice are diabetic
• catalase activity in pancreatic islet cells transgenic mice is 50-fold increased over levels in control islet cells
• in response to streptozocin, a beta-cell toxin, transgenic mice display a significantly delayed diabetogenic to a single injection, compared to control mice

endocrine/exocrine glands
• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:59725


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory