Phenotypes Associated with This Genotype

Genotype
MGI:3623483

• Allelic Composition: Tg(Ins1-Cat,Tyr)25Pne/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:59275 )

• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells

decreased circulating glucose level ( J:59275 )

• for the first 3 days after streptozocin injection, transgenic mice have decreased blood glucose levels compared to injected control mice; by day 4 transgenic and control mice are diabetic

increased catalase activity ( J:59275 )

• catalase activity in pancreatic islet cells transgenic mice is 50-fold increased over levels in control islet cells

abnormal physiological response to xenobiotic ( J:59275 )

• in response to streptozocin, a beta-cell toxin, transgenic mice display a significantly delayed diabetogenic to a single injection, compared to control mice

endocrine/exocrine glands

increased insulin secretion ( J:59275 )

• interleukin-1-beta treatment of islets from transgenic mice reduces the insulin content or stimulate insulin secretion similarly to control islet cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:59725