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Phenotypes Associated with This Genotype
Genotype
MGI:3623481
Allelic
Composition
Col1a1tm1Jcm/Col1a1+
Genetic
Background
either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1Jcm mutation (0 available); any Col1a1 mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Skeletal abnormalities in Col1a1tm1.1Jcm/Col1a1+ and Col1a1tm1Jcm/Col1a1+ mice

mortality/aging
• F1 heterozygotes die a few hours after birth from respiratory distress

respiratory system
• F1 heterozygotes die a few hours after birth from respiratory distress

skeleton
• decrease in calvarial mineralization
• exhibit multiple rib fractures
• short vertebral bodies

craniofacial
• decrease in calvarial mineralization

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteogenesis Imperfecta, Type II; OI2 166210 J:59168


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory