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Phenotypes Associated with This Genotype
Genotype
MGI:3623405
Allelic
Composition
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background
B6.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Gru mutation (12 available); any H2-Ab1 mutation (37 available)
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• diabetic transgenic mice display sialadenitis
• over 80% of transgenic mice develop diabetes (positive urine glucose test and >250 mg/dl blood glucose) beginning at 4 months of age

homeostasis/metabolism
• over 80% have blood glucose levels above 250 mg/dl
• seen in over 80% of mice

digestive/alimentary system
• diabetic transgenic mice display sialadenitis

endocrine/exocrine glands
• diabetic transgenic mice display sialadenitis

renal/urinary system
• seen in over 80% of mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:59245


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory