Mouse Genome Informatics
cx
    H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0

B6.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• diabetic transgenic mice display sialadenitis
• over 80% of transgenic mice develop diabetes (positive urine glucose test and >250 mg/dl blood glucose) beginning at 4 months of age

homeostasis/metabolism
• over 80% have blood glucose levels above 250 mg/dl
• seen in over 80% of mice

digestive/alimentary system
• diabetic transgenic mice display sialadenitis

endocrine/exocrine glands
• diabetic transgenic mice display sialadenitis

renal/urinary system
• seen in over 80% of mice

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:59245