Mouse Genome Informatics
hm
    Cln3tm1Mkat/Cln3tm1Mkat
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cellular
• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant brains

liver/biliary system
• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant livers

nervous system
• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant cerebral cortical neurons

reproductive system
• breeding success of homozygotes is significantly lower than that of wild-type or heterozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Ceroid Lipofuscinosis, Neuronal, 3; CLN3 204200 J:57155