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Phenotypes Associated with This Genotype
Genotype
MGI:3623263
Allelic
Composition
Cln3tm1Mkat/Cln3tm1Mkat
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cln3tm1Mkat mutation (1 available); any Cln3 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant brains

liver/biliary system
• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant livers

nervous system
• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant cerebral cortical neurons

reproductive system
• breeding success of homozygotes is significantly lower than that of wild-type or heterozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Ceroid Lipofuscinosis, Neuronal, 3; CLN3 204200 J:57155


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory