Mouse Genome Informatics
hm
    Calcrltm1Kmca/Calcrltm1Kmca
129S6/SvEvTac-Calcrltm1Kmca
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Generalized edema in Calcrltm1Kmca/Calcrltm1Kmca, Admtm1Unc/Admtm1Unc, and Ramp2tm1Kmca/Ramp2tm1Kmca mice

mortality/aging
• die between E13.5 and E14.5 (J:106927)
• mice die 1 to 2 days after developing edema (J:130930)

cardiovascular system
• thin vascular smooth muscle walls are seen at E12.5 and E13.5 but not at E11.5 due to a decrease in vascular smooth muscle cell proliferation
• at E12.5 and E13.5, the compact zone is discontinuous
• myocardium has a disorganized structure and the chamber appears crowded
• by E13.5, heart is about 2/3 the size of wild-type
• by E12.5, see a significant reduction in cell proliferation in the ventricles
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

homeostasis/metabolism
• at E12.5, mice exhibit interstitial edema without hemorrhage
• onset of edema is at E12.5, associated with a distended fluid-filled thoracic cavity
• the edema formation rapidly progresses so that by E13.5, all embryos exhibit hydrops fetalis

immune system
• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema
• proliferation of lymphatic endothelial cells is decreased compared to in wild-type mice

muscle
• thin vascular smooth muscle walls are seen at E12.5 and E13.5 but not at E11.5 due to a decrease in vascular smooth muscle cell proliferation
• by E12.5, see a significant reduction in cell proliferation in the ventricles
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

digestive/alimentary system
• onset of edema is at E12.5, associated with a distended fluid-filled thoracic cavity

integument
• distended skin is seen at E13.5, due to fluid accumulation in the interstitial space

cellular
• by E12.5, see a significant reduction in cell proliferation in the ventricles
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum

Mouse Models of Human Disease
OMIM IDRef(s)
Hydrops Fetalis, Nonimmune; NIHF 236750 J:106927