Phenotypes Associated with This Genotype

Genotype
MGI:3622780

• Allelic Composition: Prkdc^scid/Prkdc^scid; Tg(INS-Il10)#Sar/0
• Genetic Background: NOD.Cg-Prkdc^scid Tg(INS-Il10)#Sar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:66103 )

• transgenic NOD.scid mice receiving splenocytes from 12 week old nondiabetic Il10-nNOD mice develop diabetes (blood glucose level >300 mg/dl) by 4 weeks posttransfer (blood glucose >300 mg/dl), while no nontransgenic NOD.scid mice are affected over the same period;

• adoptive transfer of splenocytes from diabetic NOD mice into transgenic NOD.scid mice induces clinical disease with faster kinetics compared to nontransgenic NOD.scid mice

• transfer of splenocytes from prediabetic 8 week old NOD mice to transgenic NOD.scid mice caused diabetes after 4 weeks, while nontransgenic NOD.scid recipients didn't develop diabetes until 7 weeks posttransfer