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Phenotypes Associated with This Genotype
Genotype
MGI:3622418
Allelic
Composition
Il4tm1Cgn/Il4tm1Cgn
Genetic
Background
NOD.Cg-H2b Il4tm1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1Cgn mutation (6 available); any Il4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• amylase activity increases slightly between 4 and 20 weeks of age(181 to 250 U/L) compared to activity in wild-type which decreases (386 to 288 U/L)
• parotid secretory protein protease activity is retained in mutants while non-diseased animals do not show activity

endocrine/exocrine glands
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

immune system
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

vision/eye
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

digestive/alimentary system
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:105803


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory