Mouse Genome Informatics
hm
    Il4tm1Cgn/Il4tm1Cgn
NOD.Cg-H2b Il4tm1Cgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• amylase activity increases slightly between 4 and 20 weeks of age(181 to 250 U/L) compared to activity in wild-type which decreases (386 to 288 U/L)
• parotid secretory protein protease activity is retained in mutants while non-diseased animals do not show activity

endocrine/exocrine glands
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

immune system
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

vision/eye
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

digestive/alimentary system
• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls
• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls
• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:105803