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Phenotypes Associated with This Genotype
Genotype
MGI:3622312
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
NOD.Cg-Il1r1tm1Roml
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system
• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age
• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:87251


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory