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Phenotypes Associated with This Genotype
Genotype
MGI:3622096
Allelic
Composition
Abcc9tm1Cfb/Abcc9tm1Cfb
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc9tm1Cfb mutation (0 available); any Abcc9 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 30 weeks of age, 65% of males and 35% of females die suddenly

cardiovascular system
• glibenclamide-sensitive KATP current is absent in aortic smooth muscle cells
• exhibit transient, repeated episodes of coronary artery vasospasm
• calcium channel antagonists reduce coronary artery vasospasms
• exhibit repeated episodes of spontaneous ST segment elevation that are often followed by slow heart rate, however show normal baseline resting heart rate, PR intervals and QRS
• ST segment depression is seen during the recovery phase of the transient ischemic events
• do not show a drop in blood pressure with pinacidil administration or any response to glyburide as in wild-type
• seen in conscious 12- to 18-week old mice
• seen in conscious 12- to 18-week old mice

muscle
• glibenclamide-sensitive KATP current is absent in aortic smooth muscle cells
• exhibit transient, repeated episodes of coronary artery vasospasm
• calcium channel antagonists reduce coronary artery vasospasms


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory