Mouse Genome Informatics
involves: NOD
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• female mice are diabetic by 200 days of age
• female mice develop insulinemia (20ng/mL insulin vs. 2-5ng/mL in wild-type)
• female mice develop insulin resistance by 200 days of age
• mutant livers show pericellular and pericentral fibrosis

• mutants eat more than wild-type

liver/biliary system
• mutant livers show pericellular and pericentral fibrosis
• mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells
• mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g)
• liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g)
• chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis

Mouse Models of Human Disease
Alstrom Syndrome; ALMS 203800 J:107058