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Phenotypes Associated with This Genotype
Genotype
MGI:3622093
Allelic
Composition
Alms1foz/Alms1foz
Genetic
Background
involves: NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alms1foz mutation (0 available); any Alms1 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• female mice are diabetic by 200 days of age
• female mice develop insulinemia (20ng/mL insulin vs. 2-5ng/mL in wild-type)
• female mice develop insulin resistance by 200 days of age

behavior/neurological
• mutants eat more than wild-type

liver/biliary system
• mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells
• mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g)
• liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g)
• chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis
• mutant livers show pericellular and pericentral fibrosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Alstrom Syndrome; ALMS 203800 J:107058


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory