Phenotypes Associated with This Genotype

Genotype
MGI:3622070

• Allelic Composition: Tnfrsf1a^tm1Blt/Tnfrsf1a^tm1Blt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

absent follicular dendritic cells ( J:40970 )

• organized follicular dendritic cell networks are absent

abnormal Peyer's patch morphology ( J:40970 )

• the typical subepithelial dome areas fail to form

abnormal Peyer's patch follicle morphology ( J:40970 )

• B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent

decreased Peyer's patch number ( J:40970 )

• average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice

• however, T cell populations in the thymus and T and B cell populations in the spleen and lymph nodes are normal

abnormal lymph node B cell domain morphology ( J:40970 )

• B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however B cells are present and B and T cell areas are segregated

abnormal immune system physiology ( J:14424 )

decreased IgG1 level ( J:115225 )

• following treatment with MOG

increased susceptibility to type I hypersensitivity reaction ( J:92307 )

• significant reduction in bronchoalveolar lavage leukocytosis in an ovalbumin-induced allergic asthma model

decreased interleukin-6 secretion ( J:14424 )

• LPS-induced IL-6 secretion is reduced about 3-fold compared to wild-type mice; however TNF secretion is similar to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:14424 )

• infection with as few as 250 colony forming units of Listeria monocytogenes results in 100% mortality by 6 days after infection, all wild-type mice survive this treatment

• D-galactosamine sensitized homozygotes can survive 100-fold higher concentrations of LPS than wild-type; however without D-galactosamine sensitization both types of mice show similar sensitivity to LPS-induced mortality

• however, homozygotes are able to control infections of lymphocytic choriomeningitis virus

increased susceptibility to parasitic infection ( J:114203 )

• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice

• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

hematopoietic system

decreased IgG1 level ( J:115225 )

• following treatment with MOG