About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3621818
Allelic
Composition
Ikbkgtm1Mka/Ikbkg+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkgtm1Mka mutation (0 available); any Ikbkg mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 55% of the heterozygous female died by day 9 with a severely runted and anemic appearance (J:63054)
• by day 10, surviving heterozygous females showed a striped fur and a few focal hyperkeratotic lesion (J:63054)
• those survived to 1 month gained weight and looked normal (J:63054)
• approximately 55% of the heterozygous female died by day 9 with a severely runted and anemic appearance (J:63054)
• by day 10, surviving heterozygous females showed a striped fur and a few focal hyperkeratotic lesion (J:63054)
• those survived to 1 month gained weight and looked normal (J:63054)

liver/biliary system
• numbers of apoptotic cells in some heterozygous female mice at E12 (J:63054)
• numbers of apoptotic cells in some heterozygous female mice at E12 (J:63054)

growth/size/body
• about half the size and weight of normal siblings by 5 days after birth (J:63054)
• about half the size and weight of normal siblings by 5 days after birth (J:63054)

behavior/neurological
(J:63054)
(J:63054)
(J:63054)
(J:63054)

adipose tissue
• lack of subcutaneous fat in day 9 heterozygous female mice (J:63054)
• lack of subcutaneous fat in day 9 heterozygous female mice (J:63054)

immune system
• in day 9 heterozygous female (J:63054)
• massive diffuse destruction of cortical lymphocytes (J:63054)
• in day 9 heterozygous female (J:63054)
• massive diffuse destruction of cortical lymphocytes (J:63054)
• the white pulp was barely discernible and lacked a marginal zone in day 9 heterozygous female spleen (J:63054)
• the white pulp was barely discernible and lacked a marginal zone in day 9 heterozygous female spleen (J:63054)
• a patchy pigmentation that progressed to severe inflammation by 2 days after birth (J:63054)
• generalized erythematous eruption of the skin (J:63054)
• a patchy pigmentation that progressed to severe inflammation by 2 days after birth (J:63054)
• generalized erythematous eruption of the skin (J:63054)

cellular
• increased apoptosis of lymphocytes in day 9 thymus and spleen (J:63054)
• increased apoptosis of lymphocytes in day 9 thymus and spleen (J:63054)
• dispersed apoptotic keratinocytes in day 3 (J:63054)
• large clusters of apoptotic cells in day 9 epidermis (J:63054)
• dispersed apoptotic keratinocytes in day 3 (J:63054)
• large clusters of apoptotic cells in day 9 epidermis (J:63054)
• numbers of apoptotic cells in some heterozygous female mice at E12 (J:63054)
• numbers of apoptotic cells in some heterozygous female mice at E12 (J:63054)

hematopoietic system
• in day 9 heterozygous female (J:63054)
• massive diffuse destruction of cortical lymphocytes (J:63054)
• in day 9 heterozygous female (J:63054)
• massive diffuse destruction of cortical lymphocytes (J:63054)
• the bone marrow within the sternum was moderately cellular and composed almost entirely of nearly mature granulocytes in day 9 heterozygous female (J:63054)
• the bone marrow within the sternum was moderately cellular and composed almost entirely of nearly mature granulocytes in day 9 heterozygous female (J:63054)
• no megakaryocytes in the bone marrow within the sternum in day 9 heterozygous female (J:63054)
• no megakaryocytes in the bone marrow within the sternum in day 9 heterozygous female (J:63054)
• the white pulp was barely discernible and lacked a marginal zone in day 9 heterozygous female spleen (J:63054)
• the white pulp was barely discernible and lacked a marginal zone in day 9 heterozygous female spleen (J:63054)

integument
• lack of subcutaneous fat in day 9 heterozygous female mice (J:63054)
• lack of subcutaneous fat in day 9 heterozygous female mice (J:63054)
• dispersed apoptotic keratinocytes in day 3 (J:63054)
• large clusters of apoptotic cells in day 9 epidermis (J:63054)
• dispersed apoptotic keratinocytes in day 3 (J:63054)
• large clusters of apoptotic cells in day 9 epidermis (J:63054)
• a patchy pigmentation that progressed to severe inflammation by 2 days after birth (J:63054)
• generalized erythematous eruption of the skin (J:63054)
• a patchy pigmentation that progressed to severe inflammation by 2 days after birth (J:63054)
• generalized erythematous eruption of the skin (J:63054)
• sparse hair growth notable by day 5 and later becomes bald (J:63054)
• sparse hair growth notable by day 5 and later becomes bald (J:63054)
• hyperkeratotic lesions with spotty melanin deposits in certain areas (J:63054)
• lesions were shed by day 8 or 9 (J:63054)
• diffuse hyperplasia of the epidermis with multifocal hyperkeratosis and parakeratosis in tail from 8 or 9 day old (J:63054)
• hyperkeratotic lesions with spotty melanin deposits in certain areas (J:63054)
• lesions were shed by day 8 or 9 (J:63054)
• diffuse hyperplasia of the epidermis with multifocal hyperkeratosis and parakeratosis in tail from 8 or 9 day old (J:63054)
• diffuse hyperplasia of the epidermis with multifocal hyperkeratosis and parakeratosis in tail from 8 or 9 day old (J:63054)
• diffuse hyperplasia of the epidermis with multifocal hyperkeratosis and parakeratosis in tail from 8 or 9 day old (J:63054)

endocrine/exocrine glands
• in day 9 heterozygous female (J:63054)
• massive diffuse destruction of cortical lymphocytes (J:63054)
• in day 9 heterozygous female (J:63054)
• massive diffuse destruction of cortical lymphocytes (J:63054)

Mouse Models of Human Disease
OMIM ID Ref(s)
Incontinentia Pigmenti; IP 308300 J:63054


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory