Phenotypes for S1pr1 S1pr3 MGI:3621362 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1^tm1Rlp mutation (1 available); any S1pr1 mutation (30 available)
S1pr3^tm1Rlp mutation (1 available); any S1pr3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Bleeding phenotypes of mice carrying different combinations of deleted S1p receptors

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:106055 )

• die between E12.5 and E13.5

cardiovascular system

hemorrhage ( J:106055 )

• bleeding along the body and head at E12.5

limbs/digits/tail

abnormal limb morphology ( J:106055 )

• underdeveloped limbs at E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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