Analysis Tools
endocrine/exocrine glands
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• fewer developing follicles than found in control mice
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small ovary
(
J:74737
)
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small testis
(
J:74737
)
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reproductive system
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• fewer developing follicles than found in control mice
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small ovary
(
J:74737
)
|
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small testis
(
J:74737
)
|
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• multiple sperm heads are conjoined; few sperm develop as individual spermatozoa
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• females stopped breeding by 21 weeks of age
• litter sizes are smaller than produced by control mice
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• males stopped breeding by 29 weeks of age
• litter sizes are smaller than produced by control mice
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cellular
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• embryonic fibroblasts, in vitro, show hyper-responsiveness to antiproliferative effects of mitomycin C
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• embryonic fibroblasts from mutant mice, in vitro, show enhanced spontaneous chromosomal instability
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