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Phenotypes Associated with This Genotype
Genotype
MGI:3620917
Allelic
Composition
Lmnatm1Stw/Lmna+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (1 available); any Lmna mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• on a high fat diet, females develop mild insulin resistance that correlates with increased body weight, no insulin resistance is seen in males
• on a normal diet, serum glucose, insulin, and triglyceride levels are normal, insulin sensitivity and glucose tolerance
• on a high fat diet, females develop increased insulin but not glucose levels

adipose tissue
N
• no signs of lipoatrophy are seen

liver/biliary system
N
• liver morphology is normal

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Lipodystrophy, Familial Partial, Type 2; FPLD2 151660 J:75101


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory