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Phenotypes Associated with This Genotype
Genotype
MGI:3620910
Allelic
Composition
Lmnatm1Stw/Lmnatm1Stw
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (3 available); any Lmna mutation (82 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die by 4-6 weeks of age

growth/size/body

muscle

reproductive system
• spermatids and spermatozoa are largely absent
• increased frequency of leptotene and zygotene spermatocytes and decreased frequency of pachytene and diplotene spermatocytes resulting from arrest and apoptosis of spermatocytes during the pachytene stage
• however, oogenesis in females is normal
• unpaired chromosomes and/or improperly paired sex chromosomes and failure to progress through prophase I are seen

endocrine/exocrine glands

cellular
• spermatids and spermatozoa are largely absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory