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Phenotypes Associated with This Genotype
Genotype
MGI:3620650
Allelic
Composition
Ofd1tm1Bfra/Y
Tg(CAG-cre)1Nagy/0
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ofd1tm1Bfra mutation (0 available); any Ofd1 mutation (9 available)
Tg(CAG-cre)1Nagy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the expected number of males are present at E11.5 but the frequency decreases to only 4% by E12.5

embryogenesis
• embryos do not turn
• bilateral expression of normally asymmetric genes (Nodal, Pitx2) is seen

cardiovascular system
• in about 50% the heart tube remains at the midline, in the rest either normal or reversed heart looping is seen
• about 50% have a thin, abnormal cardiac tube that remains at the midline

nervous system
• at E10.5 no prospective V3 interneurons or motorneurons are detected

growth/size/body

cellular
• at E10.5 no prospective V3 interneurons or motorneurons are detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Orofaciodigital Syndrome I; OFD1 311200 J:106035


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory