Mouse Genome Informatics
cx
    Ofd1tm1Bfra/Y
Tg(CAG-cre)1Nagy/0

involves: 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• the expected number of males are present at E11.5 but the frequency decreases to only 4% by E12.5 (J:106035)

embryogenesis
• embryos do not turn (J:106035)
• bilateral expression of normally asymmetric genes (Nodal, Pitx2) is seen (J:106035)

cardiovascular system
• in about 50% the heart tube remains at the midline, in the rest either normal or reversed heart looping is seen (J:106035)
• about 50% have a thin, abnormal cardiac tube that remains at the midline (J:106035)

nervous system
• at E10.5 no prospective V3 interneurons or motorneurons are detected (J:106035)

growth/size/body

cellular
• at E10.5 no prospective V3 interneurons or motorneurons are detected (J:106035)

Mouse Models of Human Disease
OMIM IDRef(s)
Orofaciodigital Syndrome I; OFD1 311200 J:106035