Mouse Genome Informatics
cx
    B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum

NOD.Cg-B2mtm1Unc Ciitatm1Ccum
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• NOD diabetic female mice which receive islet grafts from these classI/II-deficient NOD mice remain euglycemic for up to 147 days, compared to mice receiving islet grafts from NOD or class II-deficient NOD mice which maintain euglycemia for only 6-8 days after transplant; upon removal of the graft-bearing kidney, hyperglycemia returned within 24 hours

hematopoietic system
• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals

immune system
• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals
• mice monitored to 30 weeks of age do not develop type I diabetes (2 consecutive blood glucose readings >16.5nM) while 70% of wild-type NOD mice develop diabetes

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:107051