Mouse Genome Informatics
cx
    Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0

involves: 129S2/SvPas * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• mutants have a lower degree of insulitis
• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV
• splenocytes are unresponsive to IL-12 stimulation and do not produce significant levels oi IFNgamma
• a significant reduction in CD4+ T cell-dependent (2 consecutive measures of blood glucose >250 mg/dl) diabetes incidence is observed in mutants (30%) versus controls (85%) when infected with LCMV to induce IDDM

endocrine/exocrine glands
• mutants have a lower degree of insulitis

hematopoietic system
• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:107047