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Phenotypes Associated with This Genotype
Genotype
MGI:3620118
Allelic
Composition
Stat4tm1Gru/Stat4tm1Gru
Tg(Ins2-NP)25-3Olds/0
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4tm1Gru mutation (4 available); any Stat4 mutation (31 available)
Tg(Ins2-NP)25-3Olds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mutants have a lower degree of insulitis
• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV
• splenocytes are unresponsive to IL-12 stimulation and do not produce significant levels oi IFNgamma
• a significant reduction in CD4+ T cell-dependent (2 consecutive measures of blood glucose >250 mg/dl) diabetes incidence is observed in mutants (30%) versus controls (85%) when infected with LCMV to induce IDDM

endocrine/exocrine glands
• mutants have a lower degree of insulitis

hematopoietic system
• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:107047


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory