Mouse Genome Informatics
hm
    Muc19sld/Muc19sld
NFS/N-Muc19sld
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype

Sublingual gland abnormalities in Muc19tm2Culp/Muc19tm2Culp, and Muc19sld/Muc19sld adults

digestive/alimentary system
• acinar cell differentiation is severely inhibited with almost no mucus rich cells present at birth and the number of mucus rich cells increases with age until they total about 30% of the total acinar cell population (J:9277)
• abnormal acinar cells have irregular secretion granules, irregularly dilated rough endoplasmic reticulum, and branched cisternae (J:9277)
• however, the parotid and submandibular salivary glands appear normal (J:9277)
• at 8 weeks of age submandibular gland mass normalized to body weight is increased by about 25% compared to controls, no difference in mass is seen at 3 days of age (J:85119)
• at 3 days of age the acini have characteristics of exocrine cells but have few, small, electron-dense granules, large basally oriented nuclei, tight junctions, and accumulations of glycogen (J:85119)
• however, serous demilune cell morphology is normal (J:85119)
• at 8 weeks, mucous cells contain small moderately electron-dense apical granules and cytoplasm that is much less organized with a large round nucleus surrounded by loosely arranged RER and associated Golgi than in wild-type cells (J:199625)

immune system
• in mice in which the thymus was removed at 3 days of age, severe, progressive inflammatory lesions develop in the salivary and lacrimal glands beginning at 4 weeks of age (J:20364)
• mice that underwent thymectomy and were treated with an aromatase inhibitor daily from 4 to 8 weeks of age exhibit more severe autoimmune lesions in the lacrimal and salivary glands than controls and increases in serum levels of anti-alpha-fodrin and anti-ssDNA antibodies (J:216958)

endocrine/exocrine glands
• acinar cell differentiation is severely inhibited with almost no mucus rich cells present at birth and the number of mucus rich cells increases with age until they total about 30% of the total acinar cell population (J:9277)
• abnormal acinar cells have irregular secretion granules, irregularly dilated rough endoplasmic reticulum, and branched cisternae (J:9277)
• however, the parotid and submandibular salivary glands appear normal (J:9277)
• at 8 weeks of age submandibular gland mass normalized to body weight is increased by about 25% compared to controls, no difference in mass is seen at 3 days of age (J:85119)
• at 3 days of age the acini have characteristics of exocrine cells but have few, small, electron-dense granules, large basally oriented nuclei, tight junctions, and accumulations of glycogen (J:85119)
• however, serous demilune cell morphology is normal (J:85119)
• at 8 weeks, mucous cells contain small moderately electron-dense apical granules and cytoplasm that is much less organized with a large round nucleus surrounded by loosely arranged RER and associated Golgi than in wild-type cells (J:199625)

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:20364 , J:62145 , J:106272 , J:216958