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Phenotypes Associated with This Genotype
Genotype
MGI:3619388
Allelic
Composition
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background
NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (4 available); any Ins1 mutation (33 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age

homeostasis/metabolism
• >250 mg/dl blood glucose is considered diabetic

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory