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Phenotypes Associated with This Genotype
Genotype
MGI:3619054
Allelic
Composition
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
Genetic
Background
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (4 available); any Ins1 mutation (32 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (23 available)
Tg(Ins2*Y16A)3Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 26 weeks of age, sialitis is observed but not insulitis
• no female double knockout mice carrying the transgene on a NOD background develop diabetes over 30 weeks of observation
• females lacking both insulin genes do not produce insulin autoantibodies

digestive/alimentary system
• at 26 weeks of age, sialitis is observed but not insulitis

endocrine/exocrine glands
• at 26 weeks of age, sialitis is observed but not insulitis

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory