Phenotypes Associated with This Genotype

Genotype
MGI:3619039

• Allelic Composition: Mapk8^tm1Wag/Mapk8⁺; Mapk9^tm1Mka/Mapk9^tm1Mka
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell apoptosis ( J:78190 )

• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote

abnormal T cell activation ( J:78190 )

• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote

decreased T cell proliferation ( J:78190 )

• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

hematopoietic system

decreased T cell apoptosis ( J:78190 )

• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote

abnormal T cell activation ( J:78190 )

• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote

decreased T cell proliferation ( J:78190 )

• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

cellular

decreased T cell apoptosis ( J:78190 )

• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote

decreased T cell proliferation ( J:78190 )

• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote