Mouse Genome Informatics
tg
    Tg(Ins2-GP)34-20Olds/0
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• mice are considered diabetic after a blood glucose measure of >300 mg/dl
• hypoinsulinemia is exhibited by transgenic mice accompanying increased glucose levels and islet infiltration

immune system
• on a B6 background, transgenic mice cannot exhibit a primary CTL response
• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes
• mice rapidly develop diabetes (glucose levels >300 mg/dl) 10-14 days after viral (LCMV) challenge

endocrine/exocrine glands
• mononuclear cells infiltrate the islets of transgenic mice 5-10 days after viral innoculation
• no beta cells are detected at 14 days after LCMV infection

hematopoietic system
• on a B6 background, transgenic mice cannot exhibit a primary CTL response
• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81287