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Phenotypes Associated with This Genotype
Genotype
MGI:3618987
Allelic
Composition
Tg(Ins2-GP)34-20Olds/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-GP)34-20Olds mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice are considered diabetic after a blood glucose measure of >300 mg/dl
• hypoinsulinemia is exhibited by transgenic mice accompanying increased glucose levels and islet infiltration

immune system
• on a B6 background, transgenic mice cannot exhibit a primary CTL response
• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes
• mice rapidly develop diabetes (glucose levels >300 mg/dl) 10-14 days after viral (LCMV) challenge

endocrine/exocrine glands
• mononuclear cells infiltrate the islets of transgenic mice 5-10 days after viral innoculation
• no beta cells are detected at 14 days after LCMV infection

hematopoietic system
• on a B6 background, transgenic mice cannot exhibit a primary CTL response
• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81287


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory