Phenotypes Associated with This Genotype

Genotype
MGI:3618875

• Allelic Composition: Eif4g2^tm1Yam/Eif4g2^tm1Yam
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77324 )

• at E11.5, homozygous mutant embryos are absent, with 16.7% of deciduae undergoing resorption

embryo

abnormal germ layer development ( J:77324 )

• at E7.5, homozygotes fail to develop organized primary germ layers, despite the presence of trophectoderm and primitive endoderm

failure to gastrulate ( J:77324 )

• homozygotes fail to undergo gastrulation

embryonic growth retardation ( J:77324 )

• homozygotes appear poorly developed between E7.5 and E10.5

absent mesoderm ( J:77324 )

• at E7.5, the mutant mesoderm fails to emerge from the epiblast

cellular

abnormal cell differentiation ( J:77324 )

• mutant ES cells are resistant to differentiation induced by retinoic acid (RA), and teratomas derived from them consist of undifferentiated and poorly differentiated tissues

• in addition, mutant ES cells show aberrant expression of RA-responsive genes and a selective impairment in transcription from synthetic RA-responsive elements

growth/size/body

embryonic growth retardation ( J:77324 )

• homozygotes appear poorly developed between E7.5 and E10.5