Mouse Genome Informatics
tg
    Tg(H2-Ead)12Lt/0
NOD/ShiLt-Tg(H2-Ead)12Lt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• at 40 weeks, pancreata of females show widespread invasive and destructive insulits, while males exhibit mild insulitis
• transgenic mice developed diabetes at a higher incidence when injected with cyclophosphamide at 11 weeks compared to 6 weeks of age, indicating that insulitis is increasing in severity with age
• GAD65-reactive T cells from transgenic mice produce significantly lower levels of IFNG than those from NOD controls
• IL-4 levels produced by GAD65 responsive T cells of transgenic mice are 9-fold higher compared to NOD controls
• transgenic mice develop autoimmune pathologies against salivary gland, thyroid and kidney comparable to conrol NOD mice, but no islet-directed autoimmune response is observed
• no males develop diabetes (blood glucose >300 mg/dl) during the 40 week evaluation period compared to 60% incidence in non-transgenic NOD male controls; 25% of females develop diabetes by 40 weeks compared to 90% of NOD control females

endocrine/exocrine glands
• at 40 weeks, pancreata of females show widespread invasive and destructive insulits, while males exhibit mild insulitis
• transgenic mice developed diabetes at a higher incidence when injected with cyclophosphamide at 11 weeks compared to 6 weeks of age, indicating that insulitis is increasing in severity with age

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:36435