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Phenotypes Associated with This Genotype
Genotype
MGI:3618724
Allelic
Composition
Nos3tm1Gdk/Nos3tm1Gdk
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos3tm1Gdk mutation (0 available); any Nos3 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected
• mean arterial blood pressure measured under urethane anesthesia is increased by 28 mm Hg, however do not observe cardiac hypertrophy

muscle
• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypertension, Essential 145500 J:46061


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory