Mouse Genome Informatics
hm
    Nos3tm1Gdk/Nos3tm1Gdk
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected
• mean arterial blood pressure measured under urethane anesthesia is increased by 28 mm Hg, however do not observe cardiac hypertrophy

muscle
• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected

Mouse Models of Human Disease
OMIM IDRef(s)
Hypertension, Essential 145500 J:46061