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Phenotypes Associated with This Genotype
Genotype
MGI:3618703
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (36 available); any B2m mutation (46 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present

immune system
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present
• B2m-deficient female transgenic NOD mice are completely diabetes resistant compared to transgenic NOD controls

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory