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Phenotypes Associated with This Genotype
Genotype
MGI:3618699
Allelic
Composition
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD-Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells expressing the transgenes comprise ~35% of the total peripheral blood lymphocyte population, a significant fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage
• only transgene expressing CD8+ T cells from primary splenocytes expand when cultured in presence of islets from NOD-scid donors
• transgenic CTLs generated in culture on islets exhibit cytotoxicity against a NOD-derived beta cell adenoma cell line and this is augmented when adenoma cells are pretreated with IFNG
• female NOD mice carrying both transgenes develop IDDM at a greatly increased rate compared to nontransgenic controls with disease appearing as early as 3 weeks of age

hematopoietic system
• T cells expressing the transgenes comprise ~35% of the total peripheral blood lymphocyte population, a significant fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage
• only transgene expressing CD8+ T cells from primary splenocytes expand when cultured in presence of islets from NOD-scid donors
• transgenic CTLs generated in culture on islets exhibit cytotoxicity against a NOD-derived beta cell adenoma cell line and this is augmented when adenoma cells are pretreated with IFNG

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory