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Phenotypes Associated with This Genotype
Genotype
MGI:3618697
Allelic
Composition
Tg(TcraAI4)1Dvs/0
Genetic
Background
NOD-Tg(TcraAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraAI4)1Dvs mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• T cells expressing the transgene comprise ~30% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

immune system
• T cells expressing the transgene comprise ~30% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage
• female NOD mice carrying this transgene develop IDDM at a slightly but not significantly accelerated rate compared to nontransgenic NOD controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:93553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory