Mouse Genome Informatics
ht
    Zic3tm1Bca/Zic3+
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• about 30% of males are lost between birth and weaning (J:75951)

embryogenesis
• failure, delay, or abnormal direction of turning are seen (J:75951)
• some embryos that survive beyond the turning stage show rotation defects including abnormal thoracic and lumbar flexion, and/or abnormal looping of the distal tail (including the hindlimb buds) (J:75951)
• sidedness of the malformations appears to be random (J:75951)
• seen in some embryos at E8.5 (J:75951)
• at E9.5, failure of fusion is seen in some embryos in the midbrain-hindbrain region (J:75951)
• some embryos with no other gross abnormalities show evidence of growth delay (J:75951)

nervous system
• seen in some embryos at E8.5 (J:75951)
• at E9.5, failure of fusion is seen in some embryos in the midbrain-hindbrain region (J:75951)
• seen in some pups delivered by Ceasarian sections (J:75951)
• abnormal midbrain size and structure in some embryos (J:75951)
• abnormal forebrain size and structure in some embryos (J:75951)
• exencephalic mice have a disorganized basal ganglia (J:75951)
• exencephalic mice have an anteriorly displaced diencephalon (J:75951)
• exencephalic mice have a disorganized thalamus (J:75951)
• exencephalic mice have a disorganized hippocampus (J:75951)
• exencephalic mice have a disorganized cerebral cortex (J:75951)
• seen in exencephalic mice (J:75951)
• seen in a few stillborn pups (J:75951)
• xencephalic mice have rudimentary olfactory nerves (J:75951)

cardiovascular system
• a variety of cardiac defects are seen in a subset of embryos and these embryos always also have other abnormalities (J:75951)
• an interrupted aortic arch is seen in some embryos (J:75951)
• a right aortic arch is seen in some embryos (J:75951)
• abnormal systemic venous connections (J:75951)
• one of the most common heart defects is dextro-transposition of the great arteries (J:75951)
• at E10.5 in several embryos the heart is positioned to the left side of the thorax, however in some abnormally turned embryos the heart is properly positioned at the midline and in 2 cases the heart is positioned to the right side of the thorax (J:75951)

respiratory system
• in a few embryos complete lung reversal is seen (J:75951)

digestive/alimentary system
• in some mice right sided stomach is seen (J:75951)

liver/biliary system
• in some mice reversed liver lobation is seen (J:75951)

immune system
• the spleen is always present but often hypoplastic (J:75951)

skeleton
• 2 heterozygous mice had mostly unilateral axial skeletal defects (J:75951)
• partial rib duplications and inappropriately posterior sites of rib insertion are found (J:75951)
• partial duplications and partial fusions are seen (J:75951)
• apparent homeotic transformations (J:75951)

limbs/digits/tail
• about 40% of heterozygous females have kinked tails (J:75951)

growth/size/body
• in some mice right sided stomach is seen (J:75951)
• some embryos with no other gross abnormalities show evidence of growth delay (J:75951)
• in a few embryos complete lung reversal is seen (J:75951)

hematopoietic system
• the spleen is always present but often hypoplastic (J:75951)

Mouse Models of Human Disease
OMIM IDRef(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:75951