Phenotypes Associated with This Genotype

Genotype
MGI:3618236

• Allelic Composition: Rad54b^tm1Roka/Rad54b^tm1Roka
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )

• mice hypersensitive to mitomycin C, 60% survival when given a 7.5mg/kg dose

cellular

increased cellular sensitivity to gamma-irradiation ( J:105544 )

• derived ES cells show a 1.5X increase in sensitivity to ionizing radiation which is not seen in the mice themselves

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )

• mice hypersensitive to mitomycin C, 60% survival when given a 7.5mg/kg dose