Phenotypes Associated with This Genotype

Genotype
MGI:3618185

• Allelic Composition: Plin2^tm1Chan/Plin2^tm1Chan
• Genetic Background: B6.129-Plin2^tm1Chan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:105572 )

N • normal differentiation of adipocytes and adipogenesis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:105572 , J:202513 )

N • lipolysis normal (J:105572)

N • thin layer chromatography revealed no qualitative or quantitative changes in epidermal lipids relative to control mice (J:202513)

decreased liver triglyceride level ( J:105572 )

• 57% reduction in triglycerides although triglycderides are increased in the microsomal fraction of cells

liver/biliary system

decreased liver triglyceride level ( J:105572 )

• 57% reduction in triglycerides although triglycderides are increased in the microsomal fraction of cells

decreased susceptibility to hepatic steatosis ( J:105572 )

• on a normal diet, liver has lower lipid content

decreased susceptibility to diet-induced hepatic steatosis ( J:105572 )

• on a fatty diet, density and size of lipid drops is less than in similarly fed controls although lipid levels are higher than on a normal diet

endocrine/exocrine glands

small sebaceous gland ( J:202513 )

• the mean area of sebaceous glands is significantly reduced to approximately half the size of control glands

• however, no changes in sebaceous gland morphology or gland number are observed

sebaceous gland hypoplasia ( J:202513 )

• sebaceous glands contain significantly less cells than control glands

abnormal milk composition ( J:130099 )

♀ • fat content of milk is reduced about 12% from levels seen in controls

abnormal sebaceous gland physiology ( J:202513 )

• sebaceous glands show a significant reduction in the number of proliferating cells relative to control glands, as determined by Ki67 staining

integument

small sebaceous gland ( J:202513 )

• the mean area of sebaceous glands is significantly reduced to approximately half the size of control glands

• however, no changes in sebaceous gland morphology or gland number are observed

sebaceous gland hypoplasia ( J:202513 )

• sebaceous glands contain significantly less cells than control glands

abnormal milk composition ( J:130099 )

♀ • fat content of milk is reduced about 12% from levels seen in controls

abnormal sebaceous gland physiology ( J:202513 )

• sebaceous glands show a significant reduction in the number of proliferating cells relative to control glands, as determined by Ki67 staining