Mouse Genome Informatics
hm
    Stat4tm1Gru/Stat4tm1Gru
C.129S2-Stat4tm1Gru
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• wild-type CD4+ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12
• mutant polarized Th17 CD4+ T cells fail to convert to the Th1-like state in the presence of IL-12
• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice
• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

homeostasis/metabolism
• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice
• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

hematopoietic system
• wild-type CD4+ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12
• mutant polarized Th17 CD4+ T cells fail to convert to the Th1-like state in the presence of IL-12

renal/urinary system
• onset of ischemia effects is delayed

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:106340