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Phenotypes Associated with This Genotype
Genotype
MGI:3617977
Allelic
Composition
Stat4tm1Gru/Stat4tm1Gru
Genetic
Background
C.129S2-Stat4tm1Gru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4tm1Gru mutation (4 available); any Stat4 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• wild-type CD4+ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12
• mutant polarized Th17 CD4+ T cells fail to convert to the Th1-like state in the presence of IL-12
• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice
• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

homeostasis/metabolism
• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice
• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

hematopoietic system
• wild-type CD4+ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12
• mutant polarized Th17 CD4+ T cells fail to convert to the Th1-like state in the presence of IL-12

renal/urinary system
• onset of ischemia effects is delayed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:106340


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory