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Phenotypes Associated with This Genotype
Genotype
MGI:3617975
Allelic
Composition
Stat4tm1Gru/Stat4tm1Gru
Genetic
Background
NOD.129S2-Stat4tm1Gru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4tm1Gru mutation (4 available); any Stat4 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduction in the serum level of IFNG is seen compared to diabetic and non-diabetic NOD mice
• a reduction in the serum level of IL-2 is observed compared to diabetic and non-diabetic NOD mice
• no female mutants develop diabetes (blood glucose levels above 13.9 mmol/l for 3 readings) over a 10-month period compared with 74% of female wild-type Stat4 NOD mice, which is similar to female NOD mice (80%)
• noc cellular infiltration is observed at 40 weeks of age compared to massive and invasive cellular infiltration seen in diabetic NOD controls and heterozygous Stat4 NOD or wild-type Stat4 mice
• a significant reduction in the numbers of CD4+ and CD8+ cells in islets is observed compared to diabetic NOD mice

endocrine/exocrine glands
• well-preserved insulin-positive cells are seen in the islets of mutants whereas such cells are rare in Stat4 heterozygous and wild-type Stat4 NOD mice
• compared to NOD controls, islets in Stat4 null NOD mice show well preserved insulin secretion at basal glucose levels and in response to high glucose

homeostasis/metabolism
• compared to NOD controls, islets in Stat4 null NOD mice show well preserved insulin secretion at basal glucose levels and in response to high glucose
• reduction in the serum level of IFNG is seen compared to diabetic and non-diabetic NOD mice
• a reduction in the serum level of IL-2 is observed compared to diabetic and non-diabetic NOD mice

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:90600


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory