Phenotypes for Stat4 MGI:3617975 MGI Mouse

immune system

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG is seen compared to diabetic and non-diabetic NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• a reduction in the serum level of IL-2 is observed compared to diabetic and non-diabetic NOD mice

decreased susceptibility to autoimmune diabetes ( J:90600 )

• no female mutants develop diabetes (blood glucose levels above 13.9 mmol/l for 3 readings) over a 10-month period compared with 74% of female wild-type Stat4 NOD mice, which is similar to female NOD mice (80%)

abnormal inflammatory response ( J:90600 )

• noc cellular infiltration is observed at 40 weeks of age compared to massive and invasive cellular infiltration seen in diabetic NOD controls and heterozygous Stat4 NOD or wild-type Stat4 mice

• a significant reduction in the numbers of CD4+ and CD8+ cells in islets is observed compared to diabetic NOD mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:90600 )

• well-preserved insulin-positive cells are seen in the islets of mutants whereas such cells are rare in Stat4 heterozygous and wild-type Stat4 NOD mice

abnormal insulin secretion ( J:90600 )

• compared to NOD controls, islets in Stat4 null NOD mice show well preserved insulin secretion at basal glucose levels and in response to high glucose

homeostasis/metabolism